DULUTH — Patrick Bailey and Natalie Johnson knew there were Northland clientele in need when they opened the Ketamine North Infusion Center in September 2019. The only doctor in the region who provided infusions, psychiatrist Michael Messer, had retired the year before and was concerned about what would happen to his patients.

Bailey and Johnson inherited those patients and have acquired many more over the last two and a half years. The clinic at 1003 E. Central Entrance has now provided about 5,000 infusions to clients as a treatment for depression, anxiety, post-traumatic stress disorder, bipolar depression, obsessive-compulsive disorder, substance use disorders and suicidal ideation.

Ketamine, a dissociative anesthetic, has been used in clinical settings for sedation since 1970 on humans and animals. Depending on its dosage, it can act as a hallucinogen and is used as a recreational drug, commonly known as Special K. A self-administered nasal spray, esketamine, was approved by the Food and Drug Administration in 2019 as an antidepressant.

“It’s all about dose and setting,” Johnson said. “So if you get ketamine in a rave party, what happens to you is going to be a lot different than if you’re in a recliner with a weighted blanket and a mask listening to peaceful, healing music.”

Patrick Bailey and Natalie Johnson check equipment in their office

Ketamine North co-owners Patrick Bailey and Natalie Johnson check equipment at their Duluth facility.

Clint Austin / Duluth News Tribune

That’s the setup at Ketamine North. Each patient, who must receive a referral from a physician or psychiatrist to receive an infusion, sits in dark room that resembles a spa or massage parlor room in a reclining lounge chair with an eye mask, headphones and a blanket. The infusions are given six times over a two-week period to start. The goal is to feel a change in mindset and mood after the first six sessions, then space out infusions to occasional booster doses every month, slowly weaning off. The 40-minute IV infusion invokes different feelings in each patient, sometimes causing hallucinations.

Patrick Bailey checks on a client reclining under treatment while wearing an eye mask

Ketamine North co-owner Patrick Bailey checks on a client.

Clint Austin / Duluth News Tribune

For client Cassandra Bachtell, 48, an infusion feels like an indescribable, pleasant dream, but the experience isn’t hallucinogenic for her.

“It’s kind of life free-floating outside of time and consciousness,” Bachtell said. “You don’t really realize who you are and what you are. You just are.”

She sought ketamine treatment to help her heal from a traumatic childhood that had left her mind “shackled” through her life. After trying nearly every path she could find, including medications, therapy, and several spiritual healing journeys, the studies she read about ketamine compelled her to give it a try.

Before her ketamine treatment began at Ketamine North a year and a half ago, Bachtell said her mind was like a path in a forest that she knew led to nothing good, but she didn’t know any other way. She was continuously repeating traumatic cycles because they were familiar to her. Now, she said she feels free. She’s been able to remove negative situations from her life, and said her two children have noticed a positive change in her.

Cassandra Batchell leans against a railing

Cassandra Bachtell, a client of Ketamine North, says that ketamine infusions have helped to open her mind to different ways of dealing with negative situations in her life. Bachtell is pictured Tuesday, March 8 in Duluth.

Clint Austin / Duluth News Tribune

“All of a sudden the forest had hundreds of new paths,” Bachtell said. “I had hundreds of new possibilities and instead of seeking out the familiar, I started to feel empowered to take new directions and head down new paths that were now available to me. That’s what ketamine did, and that, to me, was nothing short of miraculous.”

Bailey said some of the most powerful client transformations are those of patients with PTSD because they can relive their traumatic events and gain closure from addressing the source of their trauma.

“Ketamine is kind of like the bodyguard that goes to help you face the bullies,” he said. “So you can go in there with a more empowered view, and once you’ve seen that view and it’s not scary to you anymore, it doesn’t terrorize you anymore.”

Ketamine North has had several pediatric patients age 12 and older, which Johnson said has been slightly controversial, but the young patients have had some of the most successful reactions to ketamine that they’ve seen.

Patrick Bailey gestures while speaking in front of a window

Ketamine North co-owner Patrick Bailey talks about ketamine infusions.

Clint Austin / Duluth News Tribune

One client, a 16-year-old named Carter, whose last name the News Tribune has not published to protect his privacy, was so disabled by PTSD flashbacks and anxiety that he was no longer able to attend school or sleep, and attempted suicide several times. His aunt and guardian, Rossi Gangl, was familiar with ketamine through her time as a paramedic. After therapy, medication and attempts to treat Carter at psychiatric facilities, Gangl said ketamine was one of the only options she had left to try.

“He will tell you that ketamine saved his life and he can undoubtedly guarantee that he would have succeeded in killing himself if it weren’t for the infusions,” Gangl said. “I wholeheartedly know Carter is here because of the ketamine infusions.”

After receiving seven infusions, Carter has not needed any booster doses and is now able to live the normal life of a teenager, attending high school, playing sports and working at a part-time job. Gangl said he has not needed any medication and is anxiety- and flashback-free.

Johnson said that although ketamine can be known as a “miracle drug” for its ability to reconnect neural pathways and stop suicidal thoughts after just one treatment, ketamine infusions alone likely won’t cure someone.

“This is a tool, not a cure,” she said. “We like to say 25% therapy, 25% ketamine, 50% you. So what are you doing when you’re not getting your ketamine?”

Natalie Johnson gestures while speaking in an office

Ketamine North co-owner Natalie Johnson talks about ketamine infusions.

Clint Austin / Duluth News Tribune

They work with patients before and after their infusions to help them set healthy lifestyle changes — some as simple as leaving their home and taking a walk around the block. Johnson is in her final semester of school to become a psychiatric nurse practitioner, so Ketamine North will soon have a mental health practitioner on staff.

Ketamine is approved by the FDA as an anesthetic agent and in the nasal spray form to treat depression. However, ketamine infusions have been the subject of many research studies for depression treatment. Dr. Messer, who worked as a psychiatrist at Essentia Health, participated in one study of ketamine as a therapy for treatment-resistant depression. The study, published in 2017, showed the patient’s Beck Depression index score was reduced by 50% after five IV ketamine treatments.

Some side effects of ketamine infusions include high blood pressure and heart rates, nausea, loss of bladder control and the feeling of a hangover during the first week of treatment. At Ketamine North, patients wear a heart rate monitor on their finger and have a baby monitor in the room so they are able to communicate with Johnson and Bailey at all times.

A sign reads quiet please infusion in progress

A sign reminds visitors to Ketamine North that a treatment is in progress.

Clint Austin / Duluth News Tribune

Johnson and Bailey are both licensed nurse anesthetists who previously worked in intensive care units. They administered ketamine regularly as an anesthetic, and were interested in harnessing its antidepressant capabilities in a region where ketamine was otherwise unavailable as a treatment option.

“It’s the most gratifying thing we’ve ever done,” Bailey said. “We see people come in that have tried everything. When they first come in versus the sixth infusion, you can see the difference in their face; you can see the difference in their mannerisms.”

There are six clinics in Minnesota dedicated to ketamine infusions: Ketamine North in Duluth and five in the Twin Cities metro area. North Dakota has two ketamine clinics in Fargo. Johnson said when the clinic first opened, not everyone was aware that ketamine could be used as a mental health treatment option.

“Duluth is way behind the times, and even Minnesota is way behind the times,” Johnson said. “Opening this up up here, people were like, ‘What? What?”

Now, Johnson said the practice is more recognized thanks to word-of-mouth and awareness. Physicians and psychiatrists in the Northland have also been more open to ketamine as a treatment option than before as they send referrals to the infusion center. Ketamine North treats patients from all over the Northland region, across northern Wisconsin and Michigan’s Upper Peninsula.

Because of the high volume of clients, Johnson and Bailey are planning to open a second Ketamine North Infusion Center in Hibbing as soon as this summer.

“By healing others, you heal yourself,” Johnson said. “It’s the most gratifying thing in the world, knowing that you can truly go home and say you’ve made a difference.”

Natalie Johnson and Patrick Bailey stand outside the door of Ketamine North

Ketamine North co-owners Natalie Johnson and Patrick Bailey.

Clint Austin / Duluth News Tribune